![]() ![]() Treatment applied in our Pediatric Emergency Unit. Of activated charcoal and N-Acetylcysteine (NAC) as an antidote.1-3 TheĪim of this study was to evaluate demographic and clinical featuresĪssociated with acetaminophen overdose as well as to identify the Management of acetaminophen overdose includes gastric lavage, using As a result, this toxic metaboliteĪccumulates and causes hepatocellular injury.2 If it is used overdose, glutathione stores are depleted and theĬlearance of NAPQI is reduced. Recommended doses, NAPQI is eliminated by conjugation with glutathione. ![]() However, approximately 5-10% of the drug is metabolized byĬytochrome P450 (CYP450) to a toxic metabolite, Repeated supra-therapeutic dosingĪnd intentional or unintentional overdose usage may result in hepaticįailure.1 Acetaminophen is metabolized by glucuronidation and sulfation Although its' safety was well established, it is one KEYWORDS: Acetaminophen intoxication, N-acetylcysteine,Īcetaminophen is commonly used in children as an analgesic andĪntipyretic. Therapy are uncommon and it is generally well tolerated in children. The complication due to antidoteĬonclusions: This study confirms that the side effects due to IV NAC Twenty four patients (41%) received NAC and there were significantĭifferences in terms of acetaminophen dose, creatinine and INR betweenĪntidote and decontamination therapy groups at admission time (p= 0.00, The mean ingested acetaminophen dose was 142.1+-80 mg/kg. The mean time from ingestion to admission wasĤ.3+-4.7 h. Results: The mean age of the patients was 8.5+-6.4 y and 34 of them To evaluate the risk of acute intoxication and to determine the decision The toxic dose for acute acetaminophen intake A total of 59 patients with overdose acetaminophen ingestion were Suleyman Training and Research Hospital between August 2016 and AugustĢ017. Methods: This prospective study was conducted in Kanuni Sultan ![]() ![]() Of IV (intravenous) N-Acetylcysteine (NAC) treatment in children. Objective: To evaluate the demographic and clinical featuresĪssociated with acetaminophen overdose and to identify the clinical use Retrieved from īyline: Yakup Yesil and Abdurrahman Avar Ozdemir
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